Large-scale genome-wide association study reveals a new potential drug target for blood stem cell mobilization in humans
Stem cell transplantation is a cornerstone in the treatment of blood malignancies. In order to succeed, stem cells need to be harvested from a donor. This requires that hematopoietic stem and progenitor cells (HSPC) are mobilized from the donor’s bone marrow into the blood. In a new study, the Nilsson lab discovered DNA sequence variants that regulate HSPC levels in human blood, exposing potential
